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. 2014 Jan 9;10(1):e1003864. doi: 10.1371/journal.ppat.1003864

Figure 5. CD4+ T cell proliferation impaired in setting of heavy prior exposure.

Figure 5

A. The proliferation fold change (fraction of CFSE-lo cells following PfSE stimulation vs uRBC stimulation) is significantly reduced in children with higher prior malaria exposure (≥2 episodes ppy, n = 33) vs children with low malaria exposure (<2 episodes ppy, n = 9, P = 0.007, Wilcoxon Rank Sum. Horizontal lines show medians for each group with 95% CI). B. Impact of IL-10 blockade on CD4+ T cell proliferation following PfSE stimulation in one representative subject. The left panel shows CFSE dilution following PfSE stimulation with addition of isotype control, and the right panel shows CFSE dilution following PfSE stimulation with addition of anti IL-10 receptor α blocking antibody. C. Change in the percent of CD4+ T cells divided following isotype control vs anti IL-10 receptor α blocking antibody in a subset of 9 children from whom additional cells were available (fold change 1.7, P = 0.01).