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. 2014 Jan 9;9(1):e85715. doi: 10.1371/journal.pone.0085715

Figure 5. Effect of JNK inhibitor on release of KC, JNK activity and intramacrophagic parasite growth.

Figure 5

(A) Resident macrophages were infected or not with L. major in the presence of solvent or the indicated MAPK inhibitors. The levels of KC were determined by ELISA after 20 h of infection. (B) Macrophages were infected or not in the presence of solvent or JNK inhibitor SP600125. After 4 h, the levels of JNK and p-JNK were determined by western blotting. (C) Macrophages were infected overnight and cultured for additional 3 d in the presence of solvent or MAPK inhibitors. Intracellular load of parasites was evaluated. Results are mean and SE of the number of extracellular promastigotes produced. *P<0.05, compared to treatment with solvent.