Table 1. Significant predictors of viral structural gene substitution rates.

		Predictor	β (95% CI)	Significance
1	0.73	Neurons	−0.80 (−1.01, −0.59)	<0.0001
		Leukocytes	−0.56 (−0.80, −0.33)	<0.0001
		Hepatocytes	−0.24 (−0.40, −0.08)	0.0004
		Endothelial cells	−0.18 (−0.31, −0.05)	0.0007
2	0.73	Epithelial cells	1.13 (0.83, 1.43)	<0.0001
		Leukocytes	0.53 (0.33, 0.73)	<0.0001
3	0.73	Neurons	−0.39 (−0.53, −0.24)	<0.0001
		Epithelial cells	0.58 (0.34, 0.82)	<0.0001
		Predictor	β (95% CI)	Significance
1	0.73	Neurons	−0.80 (−1.01, −0.59)	<0.0001
		Leukocytes	−0.56 (−0.80, −0.33)	<0.0001
		Hepatocytes	−0.24 (−0.40, −0.08)	0.0004
		Endothelial cells	−0.18 (−0.31, −0.05)	0.0007
2	0.73	Epithelial cells	1.13 (0.83, 1.43)	<0.0001
		Leukocytes	0.53 (0.33, 0.73)	<0.0001
3	0.73	Neurons	−0.39 (−0.53, −0.24)	<0.0001
		Epithelial cells	0.58 (0.34, 0.82)	<0.0001

For each ANCOVA analysis, the overall adjusted R ² () of the model is given along with significant predictor variables (P<0.01) and their standardized coefficients (β) with 95% confidence intervals (CIs). In the first ANCOVA, the base levels were epithelial target cells, fecal-oral/respiratory transmission route, acute/persistent infection, species-specific host range, and dsRNA genome architecture. In the second ANCOVA, the base levels were neural target cells, bites/scratches transmission route, persistent infection, order-specific host range, and (−)ssRNA genome architecture. In the third ANCOVA, the base levels were leukocyte target cells, respiratory/vertical transmission route, acute infection, family-specific host range, and (+)ssRNA genome architecture.