Table 3. Structural gene substitution rate variation among viruses with different cell tropisms.

	N	En	L	H	Ep
N	-	0.97	1.00	1.00	1.00
En	0.03	-	0.98	1.00	1.00
L	<0.0001	0.02	-	0.99	1.00
H	<0.0001	0.001	0.006	-	0.98
Ep	<0.0001	0.0008	<0.0001	0.03	-

The significance of viruses with each target cell in the left column having higher log-scale mean substitution rates than the viruses with each target cell in the top row is designated with a p-value from a one-tailed t-test. The threshold for statistical significance (α = 0.01) was Bonferroni-corrected to account for multiple comparisons (P<0.001); the significant values are bolded. N = neurons, En = endothelial cells, L = leukocytes, H = hepatocytes, Ep = epithelial cells.