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Topographic differences between amyloid and neurodegeneration. Alzheimer's disease versus cognitively normal voxel mapping. PIB (left) statistic parametric mapping (SPM) of PIB retention ratio. MRI (right) voxel-based morphometry (VBM) of MRI grey matter density. Plaque deposition but not grey matter loss is seen in the prefrontal cortex while grey matter loss but not plaque deposition is seen in the medial and basal temporal lobes. Reprinted from [40]
