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Currents evoked by MTS modification of P2X2(I328C) receptors. A, currents elicited by hydrophobic MTS compounds (MTSM, MTSE, MTSP, and MTSTBE, each 1 mm, 60 s). Dashed lines represent base-line current level. B and C, positively charged MTS compounds evoked little or no inward current at I328C. D, I328S receptors were unaffected by MTSP (1 mm, 60 s). E, superimposed currents showing the responses of I328C receptors to MTSP at various concentrations.
