FIGURE 3.

Interactions of the coactivator peptide GRIP-1 with surface residues on holo-hRXRα-LBD. A, helical wheel view of GRIP-1 bound to holo-hRXRα-LBD illustrates its amphipathic character. B, overlay of GRIP-1 in holo-hRXRα-LBD structures containing 9cRA (green), 9cUAB30 (yellow), and Targretin (magenta). Two charge clamps between GRIP-1 and hRXRα-LBD are indicated by red dashed lines. C, side view of GRIP-1 binding to LBD showing relative positions of Glu⁴⁵⁶ and Ala⁴⁵⁷ on H12 of hRXRα-LBD to Lys⁶⁸⁶ on GRIP-1. The color code is the same as in B.