Skip to main content
. 2013 Nov 25;289(2):895–908. doi: 10.1074/jbc.M113.507913

FIGURE 6.

FIGURE 6.

LRRK2 expression levels and the G2019S mutation affect growth cone dynamics. A–H, endogenous (A–D) and stably overexpressed (E–H) LRRK2 localizes preferentially to growth cones in SH-SY5Y neurites. Note the decline in expression levels proximal of the growth cones along the neurites. Scale bar 10 μm. I, the increase in growth cone width during differentiation observed in control cells is abolished in cells over-expressing wild-type or G2019S mutant LRRK2. J, the number of filopodia per growth cone is decreased significantly in cells over-expressing wild-type LRRK2 in comparison to control cells. By contrast, the number of filopodia per growth cone is increased significantly in cells over-expressing G2019S mutant LRRK2 in comparison to wild-type over-expressing cells. *, p < 0.05; **, p < 0.01; ***, p < 0.001; n = 10.