Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
Familial LRRK2 mutations affect the LRRK2 β-tubulin interaction. A and B, quantitative YTH assays show that the introduction of familial LRRK2 mutations can increase (R1441C) as well as decrease (R1441G/H) the interaction with TUBB4 (A) and TUBB (B), whereas the R1514Q amino acid change, which does not segregate with PD, has no statistically significant effect. C, all amino acid changes decrease the RocCOR dimerization strength. *, p < 0.05; **, p < 0.01; ***, p < 0.001; n = 4.
