TABLE 1.

IC₅₀ values for synthetic peptides binding to PCSK9

Peptide ID	N-	1	2	3	4	5	6	7	8	9	10	11	12	13	-C	IC50
																μm
Pep2	Ac	V	V	F	T	S	W	Q	D	Y	L	F	W	V	Amide	37.7 ± 1.0
Pep2-2	Ac	T	V	F	T	S	W	E	E	Y	L	L	W	V	Amide	0.76 ± 0.01
Pep2-2ΔT1	Ac		V	F	T	S	W	E	E	Y	L	L	W	V	Amide	4.0 ± 0.4
Pep2-2ΔV13	Ac	T	V	F	T	S	W	E	E	Y	L	L	W		Amide	6.2 ± 0.5
Pep2-2ΔW12, V13	Ac	T	V	F	T	S	W	E	E	Y	L	L			Amide	10.0 ± 0.6
Pep2-2ΔL11-V13	Ac	T	V	F	T	S	W	E	E	Y	L				Amide	17.6 ± 3.7
Pep2-2ΔL10-V13	Ac	T	V	F	T	S	W	E	E	Y					Amide	Undetectable
Pep2-8	Ac	T	V	F	T	S	W	E	E	Y	L	D	W	V	Amide	1.4 ± 0.2
Pep-ctrl	Ac	T	V	A	T	S	A	E	E	Y	L	L	W	V	Amide	Undetectable