Table 1. Cell growth inhibitory effects and pharmacological interaction of NHI compounds and gemcitabine, in normoxic and hypoxic conditions in PANC-1 and LPC006 cells.
| |
|
IC50
(μM) |
IC50
(μM) |
IC50 |
Combination index (CI) |
|
|---|---|---|---|---|---|---|
| Cells | Condition/Drug | NHI-1 | NHI-2 | Gemcitabine | NHI-1+Gemcitabine | Pharmacological interaction results |
| PANC-1 | Normoxia | 18.2±3.7 | 22.2±2.4 | 17.9±1.3 nM | 0.45±0.12 | Synergism |
| |
Hypoxia |
1.3±0.2 |
4.0±0.06 |
0.20±0.04 μM |
0.14±0.06 |
Strong synergism |
| LPC006 | Normoxia | 16.3±2.5 | 17.8±0.1 | 7.3±1.3 nM | 0.79±0.18 | Slight synergism |
| Hypoxia | 0.9±0.4 | 1.1±0.5 | 0.15±0.03 μM | 0.29±0.53 | Strong synergism |
IC50 value: 50% growth inhibitory concentration.