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. 2013 Nov 5;110(1):94–106. doi: 10.1038/bjc.2013.692

Figure 6.

Figure 6

Transgene expression mediated by YE-PC8 is restricted to intracranial glioma cells and not post-mitotic brain cells. (A) H&E staining for normal brain tissue and human ΔGli36 glioma tumour sections. N indicates the normal brain region in the left brain (left panel). T indicates tumour region implanted in the right brain (middle panel). Interface of normal and tumour region was shown in right panel. (B) Non-invasive imaging of luciferase activities after 24 h post intracranial injection of 5 × 106, 5 × 105 or 5 × 104 PFU of YE-PC8 at both normal brain region (left brain) and tumour region (right brain). Data were presented as mean±s.e.m., n=2. (C) Corresponding quantification of photon emitted from the injection sites in (B). (D) Survival of mice harbouring the orthotopic ΔGli36 glioma after treatment with YE-PC8. Wild-type YE-102 HSV-1 virus and HBSS were also intracranially injected as control. Data were presented as mean±s.e.m., n=7.