Figure 7.

An illustration of various mechanisms through which gemcitabine enhances the efficacy of reovirus-based oncotherapy. Reovirus oncotherapy is known to target cancer through two distinct prongs: direct oncolysis (prong I) and virus-induced anti-tumour immune response (prong II). Gemcitabine also directly kills cancer cells, but also enhances the efficacy of reovirus-based therapy through immunological mechanisms, including: (1) inhibition of reovirus-induced MDSCs recruitment to the tumour microenvironment, (2) downmodulation of pro-MDSC factors, and (3) accelerated development of anti-tumour immunity.