Table 1.
Pericyte marker/location | Main function | Main physiological role | Health | Disease | Reference |
---|---|---|---|---|---|
PDGFRβ/cell surface protein | Tyrosine-protein kinase; Kinase receptor | Embryonic development, proliferation, chemotaxis, host-virus interaction | + | +/- Fibrosis Tumor Blood–brain barrier disruption | Song et al. (2005), Armulik et al. (2010), Dore-Duffy and Cleary (2011) |
αSMA/Filament protein | Contractility | Regulation of blood flow and motility | - | ++ Fibrosis Tumor Blood–brain barrier disruption | Song et al. (2005), Dore-Duffy and Cleary (2011) |
NG2/cell surface protein | Cell adhesion protein | Vasculo-genesis | + | +Fibrosis Tumor Blood–brain barrier disruption | Ozerdem et al. (2002), Dore-Duffy and Cleary (2011) |
RGS-5/intracellular protein | GTPase-activating protein | Cell motility | + | ++ Fibrosis Tumor Blood–brain barrier disruption | Song et al. (2005), Dore-Duffy and Cleary (2011) |
Desmin/filament protein | Contractility | Regulation of blood flow and motility | + | + Fibrosis Tumor Blood–brain barrier disruption | Dore-Duffy and Cleary (2011), Kamouchi et al. (2011) |
CD13/cell surface protein | Ectopeptidase | Pericyte differentiation | + | ++ Fibrosis Tumor Blood–brain barrier disruption | Armulik et al. (2010), Kamouchi et al. (2011) |
Symbols are as follow: (+) Indicates that the marker is present; (-) indicates that the marker is absent; (+/-) indicates a decrease in marker expression and; (++) indicates that the marker is over expressed.