Table 3. Glucose metabolism via glycolysis in extracts of the hippocampal formation from CD1 mice fed a control, 35% trioctanoin, or 35% triheptanoin diets.

nmol/g tissue	Control n=11	35% Trioctanoin n=10	35% Triheptanoin n=9
Glucose	1860±218	2090±255	2170±286
Glucose 6-phosphate	36.3±10.0	59.3±10.1a	14.7±1.6b
Fructose 6-phosphate	32.7±10.1	49.1±9.4a	10.1±1.2b
Fructose 1,6-biphosphate	105±11.6	62±4.5c	84±8.9
Dihydroxyacetone phosphate	0.50±0.1	0.16±0.02a	0.39±0.09
2-and 3-phosphoglycerate	21.8±3.8	11.5±1.1a	26.9±12.1
Phosphoenolpyruvate	13.5±1.5	11.3±2.5	8.3±1.9
Lactate	3400±371	3150±346	2860±330
Acetyl-CoA	1.4±0.08	1.3±0.1	1.3±0.1
β-hydroxybutyrate	92±10.1	153±7.6a	160±21.4d

Metabolite levels were quantified in polar metabolite extracts from hippocampal tissue from CD1 mice fed a standard, or 35% trioctanoin or triheptanoin diet for three weeks using liquid chromatography tandem mass spectrometry and enzymatic assays. Values represent mean±s.e.m.

^aindicates P<0.05 and between trioctanoin and control groups.

^bindicates that P<0.05 between triheptanoin and trioctanoin treatments.

^cindicates P<0.01 between trioctanoin and control.

^dindicates P<0.05 between triheptanoin and control-fed mice.