The pattern of RALDH-2/RALDH-3 expression in the dorsomedial mucosa after lesion. A–L: Immunolabeling with the RALDH-2 antisera (A,D,G,J; green) and the RALDH-3 antisera (B,E,H,K; red) and the merged images (C,F,I,L) at 2 days (A–C), 7 days (D–F), 2 weeks (G–I), and 6 weeks post-MeBr lesion (J–L). At 2 days postlesion the level of RALDH-2 remains relatively low (A–C), as is characteristic of the unlesioned mucosa. However, at 7 days post-MeBr lesion the level of RALDH-2 increases to peak levels (D–F), before subsiding by 2 weeks (G–I) and returning to essentially the prelesion state 6 weeks post-MeBr lesion RALDH-2 (J–L). In contrast, RALDH-3 remains undetectable in the dorsomedial mucosa. Arrowheads mark the basal lamina. A magenta-green version of this figure may be found online as Supporting Figure 11. Scale bar = 20 μm.