Table 1.
Severe Acute Complications in Each Observational Year
| |
Year |
|||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 2000 | 2001 | 2002 | 2003 | 2004 | 2005 | 2006 | 2007 | 2008 | 2009 | 2010 | 2011 | |
| DKA | ||||||||||||
| N |
6 |
3 |
3 |
3 |
2 |
3 |
7 |
6 |
1 |
8 |
3 |
9 |
| Ratea |
2.18 (0.80–4.75) |
0.94 (0.19–2.74) |
0.82 (0.17–2.41) |
0.77 (0.16–2.25) |
0.48 (0.06–1.73) |
0.69 (0.14–2.03) |
1.58 (0.64–3.26) |
1.31 (0.48–2.84) |
0.20 (0.01–1.14) |
1.68 (0.72–3.30) |
0.61 (0.12–1.77) |
1.90 (0.87–3.60) |
| SH | ||||||||||||
| N |
6 |
4 |
7 |
3 |
4 |
5 |
4 |
4 |
6 |
9 |
3 |
6 |
| Ratea |
2.18 (0.80–4.75) |
1.25 (0.34–3.21) |
1.92 (0.77–3.96) |
0.77 (0.16–2.25) |
0.96 (0.26–2.45) |
1.16 (0.38–2.70) |
0.90 (0.25–2.31) |
0.87 (0.24–2.23) |
1.22 (0.45–2.67) |
1.89 (0.86–3.58) |
0.61 (0.12–1.77) |
1.27 (0.46–2.76) |
| Patient-years at risk | 275 | 319.5 | 364.5 | 389 | 417.5 | 432.5 | 443 | 459.5 | 490 | 477 | 495.5 | 474 |
Diabetic ketoacidosis (DKA) was defined as an event requiring hospitalization and intravenous therapy. Severe hypoglycemia (SH) was defined as an event with a loss of consciousness and/or seizures requiring hospitalization and intramuscular and/or intravenous therapy.
a
Rates are the estimated rate per 100 patient-years (95% confidence interval).
N, total number of events.