FIG. 2.

Interaction between OXLAMs and PNPLA3 rs738409 in modulating liver injury. The figure shows the interaction between the PNPLA3 rs738409 single-nucleotide polymorphism and the 9-oxo-ODE (A) and 13-oxo-ODE (B) in modulating CK-18 levels. The continuous line represents the GG, the dotted line the CG, and the dashed line the CC. There was a positive association between the 13-oxo-ODE and 9-oxo-ODE with CK-18 only in subjects homozygous (p=0.01 and p=0.03, respectively) and heterozygous for the risk allele (p=0.006 and p=0.02, respectively), but not within the group of subjects homozygous for the common allele (p=0.77 and p=0.54, respectively).