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. 2014 Jan 10;20(2):281–294. doi: 10.1089/ars.2012.4918

FIG. 3.

FIG. 3.

Inhibition of AngII-induced hypertension and vascular O2•− production in gp91phox knockout mice (Nox2KO). (A) Blood pressure of wild-type (WT) C57Bl/6J and gp91phoxKO mice infused for 10 days with saline or AngII (0.7 mg/kg/day). (B) Measurements of cytoplasmic O2•− (DHE/HPLC) in aortas isolated from saline or AngII-infused mice. (C) Measurements of mitochondrial O2•− (MitoSOX/HPLC) in aortas isolated from saline or AngII-infused mice. Results represent mean±SEM for five to eight animals per group. *p<0.01 versus control, **p<0.05 versus AngII.