FIG. 6.

Effects of malate or mitoTEMPO treatment after the onset of AngII-induced hypertension on blood pressure (A), aortic mitochondrial superoxide (B), and aortic cytoplasm superoxide (C). Systolic blood pressure in mice infused with saline, malate, mitoTEMPO (0.5 mg/kg/day), or malate plus mitoTEMPO after the onset of AngII-induced hypertension. Following 12 days of infusion, mice were sacrificed and aortas were isolated for superoxide analysis. Results represent mean±SEM for six to eight animals per group. ^¶p<0.05 versus saline, ^§p<0.01 versus saline, *p<0.05 versus mitoTEMPO, **p<0.001 versus sham.