FIG. 3.

Dopamine (DA) catabolism, oxidative stress and aldehyde levels in WT and MAO-B^−/− mouse hearts after pressure overload. (A) MAO-B protein expression in sham-operated and 9 weeks TAC WT and MAO-B^−/− mice. (B) DA levels (left) in the myocardium of sham-operated and 9 weeks TAC (T9w) mice and DOPAC to DA ratio (right) as an index of DA catabolism in sham-operated and 9 weeks TAC mice. (C) Levels of 4-hydroxynonenal (4-HNE) in cryosections from sham-operated (n=4) and 9 weeks TAC WT (n=4, white bars) and MAO-B^−/− mice (n=4, black bars). *p<0.05, ^†p<0.001 versus sham, ^‡p<0.001 versus WT T9w. DOPAC, 3,4-dehydroxyphenylacetic acid. To see this illustration in color, the reader is referred to the web version of this article at www.liebertpub.com/ars