FIG. 5.

Apoptosis and fibrosis are reduced after pressure overload in mice lacking MAO-B. (A) Representative images of TUNEL staining in sections from WT (white bars) and MAO-B^−/− mice (black bars) at baseline (n=5, sham) and after 9 weeks of pressure overload (n=8, T9w). Arrows indicate TUNEL positive nuclei, quantified in the graph on the right. (B) Masson's Trichrome stained myocardium from WT and MAO-B^−/− mice before (n=5) and after pressure overload (n=8). Blue color reflects fibrosis (quantified on the right). *p<0.005 versus respective sham, ^†p<0.05 versus WT T9w, ^‡p<0.001 versus WT sham. WT, wild type; TUNEL, terminal deoxynucleotidyl transferase dUTP nick end labeling. To see this illustration in color, the reader is referred to the web version of this article at www.liebertpub.com/ars