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. Author manuscript; available in PMC: 2014 Dec 11.
Published in final edited form as: J Am Chem Soc. 2013 Nov 25;135(49):10.1021/ja407533e. doi: 10.1021/ja407533e

Figure 5.

Figure 5

Space-filling models of A) AIP-III and B) agonist AIP-III d-L7 displaying hydrophobic (yellow) and hydrophilic (green) surfaces. Ile1 is proposed to act as the activation anchor, and Phe5, Leu6, and Leu7 as the hydrophobic knob, in the native AIP-III. In turn, Phe5 may serve as an alternate activation anchor, and Ile1, d-Leu7, and Leu6 as an alternate hydrophobic knob, in AIP-III d-L7.