Table 2.
Conditional logistic regression analysis for the IL-2/IL-21 SNPs located in SSc considering the eight European and US populations as covariate
| Group of analysis | SNP | MAF Cases | MAF Controls | p value of each SNP conditioned by rs6822844 | p value of rs6822844 conditioned by each SNP | r2 with rs6822844
|
|||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Spain | Germany | The Netherlands | USA | Italy | Sweden | UK | Norway | ||||||
| SSc | |||||||||||||
| rs2069762 | 0.31 | 0.30 | 0.69 | 1.30E-03 | 0.06 | 0.06 | 0.09 | 0.07 | 0.07 | 0.11 | 0.06 | 0.09 | |
| rs6835457 | 0.32 | 0.34 | 0.43 | 0.024 | 0.25 | 0.37 | 0.38 | 0.36 | 0.28 | 0.48 | 0.37 | 0.49 | |
| rs907715 | 0.32 | 0.34 | 0.19 | 0.026 | 0.26 | 0.37 | 0.39 | 0.36 | 0.29 | 0.39 | 0.37 | 0.49 | |
| lcSSc | |||||||||||||
| rs2069762 | 0.31 | 0.30 | 0.69 | 9.07E-04 | – | – | – | – | – | – | – | – | |
| rs6835457 | 0.32 | 0.34 | 0.53 | 0.014 | – | – | – | – | – | – | – | – | |
| rs907715 | 0.32 | 0.34 | 0.3 | 0.015 | – | – | – | – | – | – | – | – | |
| ACA+ | |||||||||||||
| rs2069762 | 0.31 | 0.30 | 0.64 | 0.015 | – | – | – | – | – | – | – | – | |
| rs6835457 | 0.32 | 0.34 | 0.81 | 0.061 | – | – | – | – | – | – | – | – | |
| rs907715 | 0.32 | 0.34 | 0.56 | 0.063 | – | – | – | – | – | – | – | – | |
ACA, anticentromere autoantibodies; lcSSC, limited cutaneous SSc; MAF, minor allelic frequencies; SNP, single nucleotide polymorphisms; SSc, systemic sclerosis.