Table 3.

Summary of ClinSeq^® participants with arrhythmia-associated pathogenic class 5 variants

Gene	cDNA reference, predicted protein/splice alteration	Path score	ID Age Sex Race Ethnicity	QTc (mS)	ECHO septum (mm) nl 6–11	ECHO LVEF (%)nl 55–74	ECG/ECHO comments	HTN	Family history
KCNE1	NM_000219.3 c.292C>T p.Arg98Trp	5	155279 62 Female Cauc NH	438	10	65	Nl/Nl	No	Sister palpitations
KCNH2	NM_000238.3 c.934C>T p.Arg312Cys	5	173996 55 Male Cauc NH	402	10	60	SB56, 1AVB/Impaired LV diastole, moderate MR, mild AR	No	Proband palpitations, 2 paternal aunts & 1 uncle d. 70’s unknown cause

1AVB, first degree AV block; Cauc, Caucasian; d., died; LV, left ventricle; LVEF, left ventricular ejection fraction; NH, Non-Hispanic; Nl, normal; Path, pathogenicity; SB, sinus bradycardia (followed by the heart rate).