Table 2. Second cohort analysis and combined analysis of ICP associations (trend test P values).
| dbSNP identifier | Original cohort | Second cohort | Combined cohort (n=790) | Combined MAF (ICP) | MAF (C) | OR (95% CI) |
|---|---|---|---|---|---|---|
| ABCB11 | ||||||
| rs3815676 | 5.8×10−4 | 4.6×10−4 | 4.6×10−8 | 0.013 | 0.049 | 3.79 (2.30–6.26) |
| rs7577650 | 1.8×10−4 | 1.9×10−2 | 2.9×10−6 | 0.32 | 0.40 | 1.46 (1.25–1.70) |
| ABCB4 | ||||||
| rs2109505 | 4.6×10−7 | 3.3×10−6 | 1.6×10−11 | 0.11 | 0.20 | 2.06 (1.67–2.54) |
C, control; CI, confidence interval; dbSNP, single-nucleotide polymorphism database; ICP, intrahepatic cholestasis of pregnancy; MAF, minor allele frequency; OR, odds ratio.