Table 2.
Up-regulation of genes based on comparison of gene expression between control (untreated) and experimental (PGG-treated) MDAMB- 231 cells
| Genes | Accession no. | Symbol | Fold change* | p-value |
|---|---|---|---|---|
| JAK/STAT signaling pathway | ||||
| Cardiotrophin-like cytokine factor 1 | NM_013246.2 | CLCF1 | 3.75 | 0.02 |
| Colony stimulating factor 2 | NM_000758.2 | CSF2 | 7.20 | 0.02 |
| Interleukin 12A | NM_000882.2 | IL12A | 2.67 | 0.03 |
| Interleukin 15 | NM_172174.1 | IL15 | 2.05 | 0.01 |
| Interleukin 24 | NM_006850.2 | IL24 | 5.52 | 0.00 |
| Interleukin 11 | NM_000641.2 | IL11 | 4.12 | 0.00 |
| Pim-1 oncogene | NM_002648.2 | PIM1 | 2.48 | 0.03 |
| Cytokine-cytokine receptor interaction | ||||
| Chemokine (C-C motif) ligand 20 | NM_004591.1 | CCL20 | 3.25 | 0.01 |
| Cardiotrophin-like cytokine factor 1 | NM_013246.2 | CLCF1 | 3.75 | 0.02 |
| Colony stimulating factor 2 | NM_000758.2 | CSF2 | 7.20 | 0.02 |
| Interleukin 12A | NM_000882.2 | IL12A | 2.67 | 0.03 |
| Bone morphogenetic protein 2 | NM_001200.1 | BMP2 | 2.51 | 0.00 |
| Interleukin 24 | NM_006850.2 | IL24 | 5.52 | 0.01 |
| Interleukin 11 | NM_000641.2 | IL11 | 4.12 | 0.00 |
| Epidermal growth factor receptor | NM_005228.3 | EGFR | 2.88 | 0.01 |
| Interleukin 1 receptor accessory protein | NM_134470.2 | IL1RAP | 2.13 | 0.00 |
| ErbB signaling pathway | ||||
| V-abl Abelson murine leukemia viral oncogene homolog 2 | NM_005158.2 | ABL2 | 3.13 | 0.01 |
| Glycogen synthase kinase 3 beta | NM_002093.2 | GSK3B | 2.08 | 0.00 |
| Cyclin-dependent kinase inhibitor 1A (p21, Cip1) | NM_078467.1 | CDKN1A | 2.67 | 0.00 |
| Epidermal growth factor receptor | NM_005228.3 | EGFR | 2.88 | 0.01 |
| Jun oncogene | NM_002228.3 | JUN | 2.02 | 0.02 |
| Transforming growth factor, alpha | NM_003236.1 | TGFA | 2.48 | 0.00 |
| Heparin-binding EGF-like growth factor | NM_001945.1 | HBEGF | 2.18 | 0.00 |
| MAPK signaling pathway | ||||
| Dual specificity phosphatase 5 | NM_004419.3 | DUSP5 | 3.19 | 0.00 |
| Protein tyrosine phosphatase, receptor type, R | NM_002849.2 | PTPRR | 2.73 | 0.01 |
| Protein phosphatase 3 (formerly 2B), catalytic subunit, gamma isoform | NM_005605.3 | PPP3CC | 3.27 | 0.00 |
| Mitogen-activated protein kinase 7 | NM_139034.1 | MAPK7 | 2.28 | 0.00 |
| Epidermal growth factor receptor | NM_005228.3 | EGFR | 2.88 | 0.01 |
| Jun oncogene | NM_002228.3 | JUN | 2.02 | 0.02 |
| Growth arrest and DNA-damage-inducible, alpha | NM_001924.2 | GADD45A | 3.37 | 0.00 |
| VEGF signaling | ||||
| Protein phosphatase 3 (formerly 2B) | NM_005605.3 | PPP3CC | 3.27 | 0.00 |
| Prostaglandin-endoperoxide synthase 2 | NM_000963.1 | PTGS2 | 3.36 | 0.04 |
| Sphingosine kinase 1 | NM_021972.2 | SPHK1 | 2.60 | 0.00 |