Table 3.
Down-regulation of genes based on comparison of gene expression between control (untreated) and experimental (PGG-treated) MDA MB-231 cells
| Genes | Accession no. | Symbol | Fold change* | p-value |
|---|---|---|---|---|
| Pyruvate metabolism | ||||
| Pyruvate carboxylase | NM_000920.2 | PC | -2.01 | 0.03 |
| Acyl-CoA synthetase short-chain family member 2 | NM_139274.1 | ACSS2 | -2.12 | 0.03 |
| Acetyl-Coenzyme A carboxylase alpha | NM_000664.3 | ACACA | -2.37 | 0.01 |
| Acylphosphatase 2, muscle type | NM_138448.2 | ACYP2 | -2.01 | 0.00 |
| Cell cycle | ||||
| Cyclin B1 | NM_031966.2 | CCNB1 | -3.47 | 0.00 |
| Cyclin B2 | NM_004701.2 | CCNB2 | -2.17 | 0.00 |
| Transforming growth factor, beta 2 | NM_003238.1 | TGFB2 | -3.00 | 0.00 |
| Ataxia telangiectasia mutated | NM_000051.3 | ATM | -2.39 | 0.02 |
| Glycolysis / Gluconeogenesis | ||||
| Acyl-CoA synthetase short-chain family member 2 | NM_139274.1 | ACSS2 | -2.12 | 0.03 |
| Aldehyde dehydrogenase 3 family, member B1 | NM_001030010.1 | ALDH3B1 | -2.95 | 0.00 |
| Fructose-1,6-bisphosphatase 1 | NM_000507.2 | FBP1 | -2.64 | 0.02 |
| Acylphosphatase 2, muscle type | NM_138448.2 | ACYP2 | -2.01 | 0.00 |
| TGF-beta signaling pathway | ||||
| Inhibitor of DNA binding 1 | NM_181353.1 | ID1 | -3.04 | 0.02 |
| Bone morphogenetic protein 4 | NM_001202.2 | BMP4 | -3.71 | 0.01 |
| E2F transcription factor 5, p130-binding | NM_001951.2 | E2F5 | -2.27 | 0.00 |
| Transforming growth factor, beta 2 | NM_003238.1 | TGFB2 | -3.00 | 0.00 |
| Tyrosine metabolism | ||||
| Protein arginine methyltransferase 2 | NM_206962.1 | PRMT2 | -2.03 | 0.01 |
| Aldehyde dehydrogenase 3 family, member B1 | NM_001030010.1 | ALDH3B1 | -2.95 | 0.00 |
| Catechol-O-methyltransferase | NM_000754.2 | COMT | -3.03 | 0.04 |
| MAPK signaling pathway | ||||
| Ribosomal protein S6 kinase, 90 kDa, polypeptide 2 | NM_021135.4 | RPS6KA2 | -2.14 | 0.02 |
| Arrestin, beta 1 | NM_004041.3 | ARRB1 | -2.30 | 0.00 |
| CD14 molecule | NM_000591.1 | CD14 | -5.54 | 0.00 |
| Protein phosphatase 3 (formerly 2B), catalytic subunit, beta isoform | NM_021132.1 | PPP3CB | -3.02 | 0.00 |
| Transforming growth factor, beta 2 | NM_003238.1 | TGFB2 | -3.00 | 0.00 |
| JAK/STAT signaling pathway | ||||
| Interferon (alpha, beta and omega) receptor 1 | NM_000629.2 | IFNAR1 | -2.62 | 0.03 |
| Sprouty homolog 1, antagonist of FGF signaling | NM_005841.1 | SPRY1 | -2.35 | 0.00 |