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. 2012 Feb 28;33(3):235–241. doi: 10.1007/s10059-012-2201-9

Fig. 2.

Fig. 2.

Doxorubicin-induced TG2 activation is inhibited by calcium chelators and caffeine. (A, B) The effect of BAPTA-AM (20 μM), EGTA (2 mM), or TLR2-neutralizing antibody (10 μg/ml) on TG activity after exposure to doxorubicin (1 μg/ml) was monitored in HeLa cells. (C) Dose-dependent effect of caffeine. The TG activity was measured in HeLa cells after 6 h of doxorubicin treatment (1 μg/ml). (D) Time-dependent effect of caffeine. TG activity in the presence of caffeine (10 mM) was monitored in doxorubicin (1 μg/ml)-treated HeLa cells. The data represent the mean values ± standard deviations based on 3 independent experiments. **, p < 0.01.