Table 1.
Genes in top network displaying differential expression after treatment of the MCF-7 cells with Aza
| Symbol | Accession | Description | Fold change
|
|
|---|---|---|---|---|
| 5 μM Aza | 10 μM Aza | |||
| CCL20 | NM_004591.1 | Chemokine (C-C motif) ligand 20 | 2.73 | 2.41 |
| CFB | NM_001710.3 | Complement factor B | 3.07 | 2.53 |
| CNN1 | NM_001299.3 | Calponin 1, basic, smooth muscle | −6.00 | −10.0 |
| CTSS | NM_004079.3 | Cathepsin S | −2.50 | −2.25 |
| CXCL1 | NM_001511.1 | Chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha) | 2.44 | 3.33 |
| CXCL2 | NM_002089.1 | Chemokine (C-X-C motif) ligand 2 | 2.28 | 2.19 |
| DLEU1 | AW303167 | Deleted in lymphocytic leukemia, 1 | −2.25 | −10.0 |
| EBF1 | CR627349 | Early B-cell factor 1 | 2.50 | 2.60 |
| FBXO32 | NM_058229.2 | F-box protein 32 | 2.02 | 2.62 |
| GBP1 | NM_018284.1 | Guanylate binding protein 1, interferon-inducible, 67 kDa | 2.34 | 2.83 |
| HSD11B1 | NM_005525.2 | Hydroxysteroid (11-beta) dehydrogenase 1 | −3.50 | −2.25 |
| ICAM1 | NM_000201.1 | Intercellular adhesion molecule 1 (CD54), human rhinovirus receptor | 2.26 | 2.26 |
| IRF7 | NM_004029.1 | Interferon regulatory factor 7 | 2.01 | 2.21 |
| ISG15 | NM_005101.1 | ISG15 ubiquitin-like modifier | 2.28 | 2.42 |
| LCN2 | NM_005564.2 | Lipocalin 2 (oncogene 24p3) | 4.29 | 2.71 |
| LXN | NM_020169.2 | Latexin | 3.21 | 2.61 |
| MEOX2 | NM_005924.3 | Mesenchyme homeo box 2 (growth arrest-specific homeo box) | −2.67 | −2.50 |
| MVP | NM_005115.3 | Major vault protein | 2.50 | 2.54 |
| MX2 | NM_002463.1 | Myxovirus (influenza virus) resistance 2 (mouse) | 2.32 | 2.72 |
| NEFH | NM_021076.2 | Neurofilament, heavy polypeptide 200 kDa | 2.22 | 2.20 |
| NOTCH4 | NM_004557.3 | Notch homolog 4 (Drosophila) | −3.00 | −5.00 |
| OAS1 | NM_002534.1 | 2′,5′-oligoadenylate synthetase 1, 40/46 kDa | 3.47 | 2.56 |
| ORM1/ORM2 | NM_000607.1 | Orosomucoid 1 | 5.56 | 4.52 |
| POSTN | NM_006475.1 | Periostin, osteoblast specific factor | −3.00 | −3.00 |
| S1PR3 | NM_001001938.1 | Endothelial differentiation, sphingolipid G-protein-coupled receptor, 3 | 2.66 | 2.05 |
| SAMD4A | BX092102 | Sterile alpha motif domain containing 4A | −2.50 | −2.50 |
| SERPINF1 | NM_002615.4 | Serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1 | 3.34 | 2.95 |
| SP100 | AK160379 | SP100 nuclear antigen | 2.86 | 2.43 |
| ST6GAL1 | NM_173216.1 | ST6 beta-galactosamide alpha-2,6-sialyltranferase 1 | 4.60 | 2.87 |
| SYNPO | AB028952 | Synaptopodin | 2.91 | 2.76 |
| TFPI2 | NM_006528.2 | Tissue factor pathway inhibitor 2 | 2.01 | 2.82 |
| TIMP3 | NM_000362.3 | Tissue inhibitor of metalloprotei--se 3 (Sorsby fundus dystrophy, pseudoinflammatory) | 4.60 | 4.41 |
| TNF | NM_000594.2 | Tumor necrosis factor (TNF superfamily, member 2) | 2.08 | 2.75 |
| TNFSF10 | NM_003810.2 | Tumor necrosis factor (ligand) superfamily, member 10 | 2.07 | 2.13 |
| TP53INP1 | NM_033285.2 | Tumor protein p53 inducible nuclear protein 1 | 3.99 | 6.85 |