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. 2012 May 18;33(6):563–574. doi: 10.1007/s10059-012-2294-1

Fig. 7.

Fig. 7.

Proposed model of HA-promoted angiogenesis. HA induces an interaction between CD44 and PKCδ. Activation of PKCδ leads to the induction of RHAMM via AP-1. PKCδ is also necessary for the activation of ERK. HA induces an interaction between RHAMM and ERK. HA transactivates TGFβRI via PKCδ and ERK. The activation of TGFβRI by HA is closely associated with degradation of HDAC3, which results from tyrosine nitration induced by rac1. The decreased expression of HDAC3 is responsible for the induction of PAI-1 and MMP-2.