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. 2012 Jun 7;33(6):545–551. doi: 10.1007/s10059-012-2267-4

Fig. 5.

Fig. 5.

Knockdown of TGF-beta RII could reverse the effect of inhibition of miR-590-5p in HepG2 cells. (A) TGF-bRII siRNA could knockdown the upregulation of TGF-b RII by miRNA-590-5p inhibitor to rescue the proliferation of HepG2 cells. Control means cells transfected with miRNA inhibitor control and siRNA control. The protein expression of TGF-beta RII is shown at the bottom. All data are presented as means ± s.d. of three independent experiments. *p < 0.05, **p < 0.01. (B) Knockdown of TGF-beta RII could reverse the decrease of invasion caused by miR-590-5p inhibitor as determined by a transwell assay in HepG2 cells. Representative images are shown at the top, and the quantification is shown at the bottom. Representative photomicrographs of the membrane-associated cells assayed using hochest33342 staining (200×) are shown. All data are presented as means ± s.d. of three independent experiments. *p < 0.05, **p < 0.01.