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Chromatin loop formation it the β-globin loci. The globin genes are closely positioned with HS-60/62, HS5, LCR and 3′HS1 in the mouse β-globin locus when they are actively transcribed. In the human locus, the fetal genes and adult genes are in close proximity with HS5, LCR, and 3′HS1 when they are transcribed. The close positioning of active genes with HSs makes chromatin loops by extruding regions between them.
