Table 2.
Differential protein expression altered in bi-1−/− mice
| Spot no. | Protein name | Average ratio (bi-1−/−/bi-1+/+) | Tissue specificity (found in this study) | Subcellular locationa | Biological processa |
|---|---|---|---|---|---|
| 1α, 1β | Glucose-regulated protein 75 (GRP75/mortalin/PBP74/mthsp70) | pI shift | Liver, brain, kidney, heart | Mitochondria, cytoplasm | Protein export from nucleus, protein folding, response to stress |
| 2α, 2β | Peroxiredoxin-6 (Prx6) | pI shift | Liver, brain, kidney, heart, lung | Cytoplasm, lysosome, lung secretory organelles | Lipid catabolism, bleb formation, cell redox homeostasis, oxidation reduction, response to ROS |
| 3α, 3β | Fumarylacetoacetate hydrolase (FAH) | pI shift | Liver, kidney | Unknown | Phenylalanine, tyrosine, arginine catabolism |
| 4α, 4β | Selenium-binding protein 2 (SBP2) | 1.608 | Liver | Nucleus, cytoplasm, cytosol, membrane, peripheral membrane protein | Protein transport, selenium binding |
| 5 | Phosphatidylethanolamine-binding protein 1 (PEBP-1) | −2.860 | Liver | Cytoplasm | ATP-binding, lipid binding, protease and serine protease inhibitor |
| 6 | Ferritin light chain 1 | 1.610 | Liver | Unknown | Cellular iron ion homeostasis and transport |
a
Information from UniProtKB and NCBI