Fig. 4.

Underlying network of prioritized loci for cisplatin induced cytotoxicity (IC₅₀). (A) Identified interaction examples between prioritized SNPs and gene expressions, which derives phenotypic variations, cytotoxicity (IC₅₀). (B) Detailed examples of functional prioritization of SNPs. (Left and Middle) Prioritized case due to the significant p-value of SNPs, associated expressions and lower p-value for the interactions between SNPs and expressions. (Right) Non-prioritized case for the significant p-value of SNP due to the higher p-value for interactions between SNPs and gene expressions. (C) Conserved interactions network of causal loci for trait variation, IC₅₀, in CEU and YRI populations.