Table 1.
Prepared p-values of SNPs, gene expression, and their interactions
| Trait-associated features (Cisplatin-derived cytotoxicity, IC50 and AUC) | Population
|
Resources | |
|---|---|---|---|
| CEU^ | YRI^ | ||
| Total no. of SNPs (p-value < 0.01)# | 30,807 | 41,112 | PACdb |
| IC50-associated SNPs (loci)* | 24,719 | 34,395 | |
| Number of corresponding genes | 1,938 | 3,289 | |
| Mean of the p-value | 0.0049 | 0.0047 | |
| Standard deviation of the p-value | 0.0029 | 0.0029 | |
| Total no. of gene expression patterns (p-value < 0.01)# | 541 | 825 | PACdb |
| IC50-associated gene expression* | 492 | 683 | |
| Mean of the p-value | 0.0039 | 0.0035 | |
| Standard deviation of the p-value | 0.0029 | 0.003 | |
| Interactions between SNPs and gene expression** | 44,501 | 58,804 | SCAN |
| Mean of the p-value | 0.00006 | 0.00005 | |
| Standard deviation of the p-value | 0.00004 | 0.00004 | |
#
Number of features associated with cisplatin-derived cytotoxicity: IC50 and AUC (area under the concentration-time curve).
*
Number of selected features associated with the target trait (cisplatin-derived IC50).
**
Number of interactions between SNPs and gene expression (p-value < 0.01).
^
CEU, Utah residents with Northern and Western European ancestry; YRI, residents of Yoruba in Ibadan, Nigeria. Detailed information on these populations is available through the web site of the HapMap project (www.hapmap.org).