Fig. 3.

Cytokine secretion in p190RhoGEF TG mice after LPS injection. Age-matched mice (LtM control or p190RhoGEF TG, three mice in each group) were injected with either PBS or LPS (25 μg) for 6 h as described in the “Materials and Methods”. Each mouse serum was collected by eye bleeding and was diluted serially. The level of IL-12 (A) or IL-6 (B) in the serum of each mouse was compared by ELISA. Experiments were performed in three distinct TG lineages at least and repeated more than three times. The data are the mean ± SD of three independent experiments. Statistical significance was analyzed by two-way ANOVA with Bonferroni multiple comparison tests. Significant comparisons are noted as ^**, p < 0.01.