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Effects of S1P on pacemaker currents in cultured ICC from mouse small intestine. (A, B, and C) Pacemaker currents from ICC exposed to S1P (0.1, 0.5, and 1 μM) at a holding potential of −70 mV. Responses to S1P are summarized in (D, E, and F) (n = 5). Bars represent mean values ± SE. *(P < 0.05) Significantly different from the untreated control. Dotted lines indicate the zero current levels. Con, control.
