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. 2013 Jan 9;35(1):79–86. doi: 10.1007/s10059-013-2282-0

Fig. 6.

Fig. 6.

Effects of PD 98059, SB 203580, or JNK inhibitor II on S1P-induced actions in cultured ICC from mouse small intestine. (A) Pre-treatment with PD 98059 (10 μM) did not result in blockade of S1P (1 μM)-induced actions at a holding potential of −70 mV. (B) Pre-treatment with SB 203580 (10 μM) did not result in blockade of S1P (1 μM)-induced actions at a holding potential of −70 mV. (C) Pre-treatment with JNK inhibitor II (10 μM) resulted in suppression of S1P (1 μM)-induced actions at a holding potential of −70 mV. Responses to PD 98059, SB 203580, or JNK inhibitor II on S1P-induced actions are summarized in (D), (E), and (F) (n = 4). Bars represent mean values ± SE. *(P < 0.05) Significantly different from S1P alone. Dotted lines indicate the zero current levels. Con, control; PD, PD 98059; SB, SB 203580; JNK, JNK inhibitor II.