Table 1.
Localization and activity of mammalian sirtuins
| Sirtuin | Activity | Localization | Interactions | Biological connections |
|---|---|---|---|---|
| SIRT1 | Deacetylation | Nucleus | FOXO1, FOXO3, PGC1α, p53, eNOS | Cell survival & Metabolism |
| SIRT2 | Deacetylation | Cytosol | FOXO1, NF-κB | Cell cylcle & Inflammation |
| SIRT3 | Deacetylation | Mitochondria | SOD2, IDH2 | Redox regulation & Metabolism |
| SIRT4 | ADP-ribosylation | Mitochondria | GDH | Insulin secretion & Metabolism |
| SIRT5 | Deacetylation | Mitochondria | CPS1 | Urea cycle |
| SIRT6 | Deacetylation, ADP-ribosylation | Nucleus | H3K9, H3K56 | DNA repair |
| SIRT7 | Unknown | Nucleus | Unknown | rDNA transcription |
CPS1, carbamoyl phosphate synthetase 1; eNOS, endothelial nitric oxide synthase; FOXO, forkhead box O; GDH, glutamate dehydrogenase; H3K9, histone H3 lysine 9; H3K56, histone H3 lysine 56; IDH2, isocitrate dehydrogenase 2; NF-κB, nuclear factor-κB; PGC1 α, peroxisome proliferator-activated receptor-γ co-activator 1 α; SOD2, superoxide dismutase 2