Table 4.
Upstream regulator analysis of oxidation-sensitive proteins by Ingenuity system
| Molecule type | Upstream regulator | p-value of overlapa | Target molecules in dataset |
|---|---|---|---|
| Chemical-endogenous mammalian | Hydrogen peroxide | 1.72E-03 | ACTG2, ANXA2, HSPA1A/HSPA1B, PDIA3 |
| beta-Estradiol | 3.82E-03 | ACTG2, HSPA1A/HSPA1B, KRT10, KRT17, KRT4, LMNA, PDIA3 | |
| UDP-D-glucose | 8.75E-03 | PDIA3 | |
| P1, P4-Di(adenosine-5′) tetraphosphate | 1.17E-02 | TPSAB1/TPSB2 | |
| Mannose | 1.60E-02 | PDIA3 | |
| Butyric acid | 1.69E-02 | ANXA2, MVP, PDIA3 | |
| Sucrose | 2.75E-02 | PDIA3 | |
| S-adenosylmethionine | 3.31E-02 | ACTG2 | |
| Prostaglandin D2 | 3.60E-02 | HSPA1A/HSPA1B | |
| Growth factorb | TGFB1 (includes EG:21803) | 1.26E-05 | ACTG2, ACTN1, ANXA2, COL6A1, HSPA1A/HSPA1B, KRT10, KRT17, MYH9, TPSAB1/TPSB2, TUBB4B |
| INHA | 4.11E-04 | ACTG2, COL6A1, LMNA | |
| ANGPT2 | 4.36E-04 | HSPA1A/HSPA1B, PDIA3, PDIA6 | |
| INHBA | 1.41E-03 | ACTG2, ACTN1, TPSAB1/TPSB2 | |
| PDGFC | 1.31E-02 | ACTG2 | |
| MDK | 1.45E-02 | ACTG2 | |
| VEGFA | 3.60E-02 | LMNA, SLC25A5 | |
| JAG1 | 3.74E-02 | ACTG2 | |
| MSTN | 3.88E-02 | ACTG2 |
a
The overlap p-value is a statistically significant overlap between the dataset genes and the genes that are regulated by regulator. It is calculated using Fisher’s Exact Test, and significance is generally attributed to p-values < 0.01.
b
TGFB1, transforming growth factor, beta 1; INHA, alpha-inhibin; ANGPT2, angiopoietin 2; INHBA, inhibin, beta A; PDGFC, platelet-derived growth factor C; MDK, midkine (neurite growth-promoting factor 2); VEGFA, vascular endothelial growth factor A; JAG1, jagged 1; MSTN, myostatin.