Fig. 5.

pLTA reduces the accumulation of macrophages and monocytes in hyperlipidemic ApoE^−/− mice. (A) Upper panel shows cross-sections of mouse macrophages in the aortic sinus of ApoE^−/− mice which stained positively for the monoclonal antibody MOMA-2. The mice were fed a HFHC diet and injected with PBS or pLTA. Lower panel shows % of monocytes/macrophage positive area in total lesion area. Three sections from each animal were stained to determine the mean. Data is represented as the percentage of the total lesion area. (B) Upper panel shows the same crosssections as (A) stained with Oil Red O. Areas of aortic sinus lesions staining positively for Oil Red O were quantified by computer assisted morphometry (Lower panel) (*p < 0.05).