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. 2013 Feb 21;35(2):142–150. doi: 10.1007/s10059-013-2293-x

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Fig. 4. — Active PLC inhibitor U-73122 blocking the gintonin action on P2X₁ receptor desensitization. (A) Representative trace showing the gintonin-mediated I_ATP potentiation in Xenopus oocytes expressing human P2X₁ receptors. (B, C) Representative trace showing the effects of active (U73122) and inactive (U73343) PLC inhibitors (each 1 μM) on the gintonin-mediated I_ATP potentiation. The active PLC inhibitor (1 μM) blocks both gintonin-evoked CaCC and I_ATP potentiation. (D) Histograms summarizing the effects of the active or inactive PLC inhibitors on gintoninmediated I_ATP potentiation (*p < 0.001, compared to control). Data represent the mean ± SEM (n = 5/group).