Table 2.
Sirtuins regulated by miRNAs
| Sirtuin | Localization | Activity | Target | Function | miRNAs |
|---|---|---|---|---|---|
| SIRT1 | Nucleus, Cytosol | Deacetylation | PGC-1α, FOXO, p53, HIF1a, SREBP-1c, CREB, NF-κb, FXR, LXR, and more | Metabolism, Inflammation, Cell cycle/apoptosis, Stress response | miR-9, miR-22, miR-34a, miR-34c, miR-132, miR-143, miR-146, miR-181, miR-217 and more |
| SIRT2 | Cytosol, Nucleus | Deacetylation | PEPCK, FOXO1, PAR3, Tubulin | Cell cycle Tumorigenesis | Not known |
| SIRT3 | Mitochondria, Nucleus | Deacetylation | LCAD, HMGCS2, GDH, IDH2 and more | Metabolism | Not known |
| SIRT4 | Mitochondria | ADP-ribosylation | GDH | Insulin secretion, Fatty acid oxidation | Not known |
| SIRT5 | Mitochondria | Deacetylation,Demalonylation, Desuccinylation | CPS1 | Urea cycle | Not known |
| SIRT6 | Nucleus | Deacetylation, ADP-ribosylation | H3K9, H3K56, SIRT6 | DNA repair, Metabolism | miR-33a/33b, miR-766 |
| SIRT7 | Nucleus | Not Known | Not Known | rDNA transcription | miR-125a, miR-125b |