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Effect of CCN4 on VSMCs migration and proliferation through integrin. (A) CCN4-induced VSMCs migration in a dose-dependent manner. (B) VSMCs migration was regulated by α5β1. (C) VSMCs proliferation was mediated by α5β1. (D) Anti-CCN4 antibody declined BrdU incorporation in a concentration-dependent manner. (A-D) Data are mean ± SD of six dishes from three separate experiments. *P < 0.05, **P < 0.01 compared with control.
