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Knockdown of CCN4 by siRNA inhibited the VSMC proliferation in vitro. (A) The number of VSMCs. (B) The incorporation of BrdU by VSMCs. There was a significant reduction in cells numbers and incorporation of BrdU, while the pretreatment of cells with the recombinant CCN4 protein reversed the effect of CCN4 knockdown on VSMC proliferation and BrdU uptake in a dose-dependent manner. *P < 0.05 compared with control.
