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Hypoxia induces MMP disruption and this damage can be influenced by S82 mutations. Red fluorescence detection in H9c2-(A) and HeLa (B) cell lines including Con, S82E and S82A groups under normoxia and hypoxia conditions shows different MMP damage according to groups. The histogram to the right represents the quantified MMP reduction respectively as mean ± SEM (n = 3). #P < 0.05; *P < 0.01 vs. N, & P < 0.05 vs. Con.
