Fig. 8.

Proposed mechanism of modulation of MTs and mitochondrial function in hypoxia by DYNLT1 phosphorylation at S82. Our data demonstrated that hypoxia can induce DYNLT1 phosphorylation at S82, which is involved in MTs and mitochondrion tuning. S82E makes this damage even worse while S82A prevents hypoxia-induced cellular dysfunction. Consequently, phosphorylation of S82 does play a role in MT assembly and mitochondrial permeabilization regulation and should be involved in studies dealing with cellular hypoxic tolerance.