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. 2013 Jul 24;30(10):2328–2346. doi: 10.1093/molbev/mst130

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© The Author 2013. Published by Oxford University Press on behalf of the Society for Molecular Biology and Evolution.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.

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Fig. 6. — Canonical Wnt pathway (dkk-1, r-spondin-1, and fst) transcriptional regulation after Dmrt1a/Dmrt1bY overexpression in different cell lines. dkk-1 (A–D), r-spondin-1 (E–H), and fst (I–L) expression was monitored in different cell lines (SG3 and OLF) following Dmrt1a or Dmrt1bY overexpression. Transcription of dkk-1 and r-spondin-1 is upregulated by both Dmrt1s (A–H). Differential regulation of fst is observed. While no regulation was observed after Dmrt1bY overexpression, fst transcription is clearly upregulated in both cell lines overexpressing Dmrt1a (I–L).