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. Author manuscript; available in PMC: 2014 Jan 10.
Published in final edited form as: Nat Biotechnol. 2012 Jul 10;30(7):658–670. doi: 10.1038/nbt.2287

Figure 2.

Figure 2

Factors constraining intratumoral virus spread (host innate or acquired immunity and extracellular matrix) and solutions to circumvent them.